Ph. D. Students

Wångsell, F., Nordeman, P., Sävmarker, J., Emanuelsson, R., Jansson, K., Rosenquist, Å., Samuelsson, B., Larhed, M. Investigation of α-phenylnorstatine and α-benzylnorstatine as transition state isostere motifs in the search for new BACE-1 inhibitors. Manuscript (2009).

Wångsell, F., Gustafsson, K., Kvarnström, I., Borkakoti, N., Edlund, M., Jansson, K., Lindberg, J., Hallberg, A., Rosenquist, Å., Samuelsson, B. Synthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core. Euro. J. Med. Chem., (2009), accepted.

doi:10.1016/j.tet.2009.09.106

Wångsell, F., Russo, F., Sävmarker, J., Rosenquist, Å., Samuelsson, B., Larhed, M. Design and synthesis of BACE-1 inhibitors utilizing a tertiary hydroxyl motif as the transition state mimic. Bioorg. Med. Chem. Lett., 19(16), (2009) 4711-4714.

doi:10.1016/j.bmcl.2009.06.065

Thorstensson, F., Wångsell, F., Kvarnström, I., Vrang, L., Hamelink, E., Jansson, K., Hallberg, A., Rosenquist, Å., Samuelsson, B. Synthesis of novel potent hepatitis C virus NS3 protease inhibitors: Discovery of 4-hydroxy-cyclopent-2-ene-1,2-dicarboxylic acid as a N-acyl-4-hydroxyproline bioisostere. Bioorg. Med. Chem., 15(2), (2007) 827-838.

doi:10.1016/j.bmc.2006.10.044   

Bäck, M., Johansson, P-O., Wångsell, F., Thorstensson, F., Kvarnström, I., Ayesa, S., Wähling, H., Pelcman, M., Jansson, H., Lindström, S., Wallberg, H., Classon, B., Rydergård, C., Vrang, L., Hamelink, E., Hallberg, A., Rosenquist, Å., Samuelsson, B. Novel potent macrocyclic inhibitors of the hepatitis C virus NS3 protease: Use of cyclopentane and cyclopentene P2-motifs. Bioorg. Med. Chem., 15(22), (2007) 7184-7202.

Wångsell, F. 2009. Design and Synthesis of Aspartic and Serine Protease Inhibitors.

Targeting the BACE-1 and the HCV NS3 Protease. Acta Universitatis Upsaliensis. Digital

Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy 108. 71

pp. Uppsala. ISBN 978-91-554-7623-6.