Papers

A. Poliakov, A. Johansson, E. Åkerblom, K. Oscarsson, B. Samuelsson, A. Hallberg, U. H. Danielson:

Structure-activity relationships for the selectivity of hepatitis C virus NS3 protease inhibitors.

Biochim Biophys Acta 1672 (2004) 51-59.

 

M. Graffner-Nordberg, K. Kalmodin, J. Åqvist, S. Queener, A. Hallberg:

Design, synthesis, and computational affinity prediction of ester soft drugs as inhibitors of dihydrofolate reductase from Pneumocystis carinii.

Eur J Pharm Sci 22 (2004) 43-54.

 

J. Lindberg, D. Pyring, S. Lövgren, Å. Rosenquist, G. Zuccarello, I. Kvarnström, H. Zhang, L. Vrang, B. Classon, A. Hallberg, B. Samuelsson, T. Unge:

Symmetric fluoro-substituted diol-based HIV protease inhibitors. Ortho-fluorinated and meta-fluorinated P1/P1'-benzyloxy side groups significantly improve the antiviral activity and preserve binding efficacy.

Eur J Biochem 271 (2004) 4594-4602.

 

U. Rosenström, C. Sköld, G. Lindeberg, M. Batros, F. Nyberg, A. Karlén, A. Hallberg:

A selective AT2 receptor ligand with a γ-turn-like mimetic replacing the amino acid residues 4-5 of angiotensin II.

J Med Chem 47 (2004) 859-870.

 

K. Ersmark, I. Feierberg, S. Bjelic, E. Hamelink, F. Hackett, M. J. Blackman, J. Hultén, B. Samuelsson, A. Hallberg:

Potent inhibitors of the P. falciparum enzymes plasmepsin I and II devoid of cathepsin D inhibitory activity.

J Med Chem 47 (2004) 110-122.

 

Y. Wan, C. Wallinder, B. Johansson, M. Holm, A. K. Mahalingam, X. Wu, M. Butros, A. Karlén, A. Pettersson, F. Nyberg, L. Fändriks, A. Hallberg, M. Alterman:

The first reported non-peptide AT1 receptor agonist L-162,313 acts as an AT2 receptor agonist in vivo.

J Med Chem 47 (2004) 1536-1546.

 

P. O. Johansson, Y. Chen, A. K. Belfrage, M. J. Blackman, I. Kvarnström, K. Jansson, L. Vrang, E. Hamelink, A. Hallberg, Å. Rosenquist, B. Samuelsson:

Design and synthesis of potent inhibitors of the malaria aspartyl proteases plasmepsin I and II. Use of solid phase synthesis to explore novel statin motifs.

J Med Chem 47 (2004) 3353-3366.

 

U. Rosenström, C Sköld, G. Lindeberg, M. Botros, F. Nyberg, A. Karlén, A. Hallberg:

Synthesis and AT2 receptor binding properties of angiotensin II analogues.

J Peptide Res 64 (2004) 194-201.

 

Y. Wan, C. Wallinder, B. Plouffe, H. Beaudry, A. K. Mahalingam, X. Wu, B. Johansson, M. Holm, M. Botros, A. Karlén, A. Pettersson, F. Nyberg, L. Fändriks, N. Gallo-Payet, A. Hallberg, M. Alterman:

Design, synthesis and biological evaluation of the first selective non-peptide AT2 receptor agonist.

J Med Chem 47 (2004) 5995-6008.

 

P. Johannesson, G. Lindeberg, Máte Erdélyi, P.-A. Frändberg, F. Nyberg, A. Karlén, A. Hallberg:

AT2 selective angiotensin II analogues encompassing tyrosine functionalized 5,5-bicyclic thiazabicycloalkane dipeptide mimetics.

J Med Chem 47 (2004) 6009-6019.

 

A. Stadler, H. Schenck, K. Vallin, M. Larhed, A. Hallberg:

Terminal Heck vinylations of chelating vinyl ethers.

Adv. Synth. Catal 346 (2004) 1773-1781.

 

A. K. Roos, C. E. Andersson, T. Bergfors, M. Jacobsson, A. Karlen, T. Unge, T. A. Jones and S. L. Mowbray:

Mycobacterium tuberculosis Ribose-5-phosphate Isomerase has a Known Fold, but a Novel Active Site.

Journal of Molecular Biology 335, 799-809 (2004).

 

L. Afzelius, I. Zamora, C. M. Masimirembwa, A. Karlén, T.B. Andersson, S. Mecucci, M. Baroni M. and G. Cruciani:

Conformer- and alignment-independent model for predicting structurally diverse competitive CYP2C9 inhibitors.

Journal of Medicinal Chemistry 47, 907-14 (2004).

 

L. Afzelius, F. Raubacher, A. Karlén, F.S. Jørgensen, T.B Andersson, C. M Masimirembwa and I. Zamora:

Structural analysis of CYP2C9 and CYP2C5 and an evaluation of commonly used molecular modelling techniques

Drug Metabolism and Disposition 32, 1218-29 (2004).

 

A. Svennebring, P. Nilsson and M. Larhed:

Microwave-Accelerated and Chelation-Promoted Double Terminal Arylations of Vinyl Ethers: Further Evidence for Palladium(0) Release from Phosphapalladacycles.

J. Org. Chem., 69 (2004) 3345-3349

 

K. Orrling, P. Nilsson, M. Gullberg and M. Larhed:

An Efficient Method to Perform Milliliter-Scale PCR Utilizing Highly Controlled Microwave Thermocycling.

Chem. Commun., (2004) 790-791

 

K. Ersmark, M. Larhed and J. Wannberg:

Microwave-Enhanced Medicinal Chemistry: A High-Speed Alternative for Convenient Preparation of Protease Inhibitors.

Current Opinion in Drug Discovery & Development, 7 (2004) 417-427

 

M. M. S. Andappan, P. Nilsson, H. von Schenck and M. Larhed:

Dioxygen Promoted Regioselective Oxidative Heck Arylations of Electron-Rich Olefins with Arylboronic Acids.

J. Org. Chem., 69 (2004) 5212-5218

 

K. Olofsson and M. Larhed:

Microwave-Assisted Fluorous Chemistry.

Handbook of Fluorous Chemistry, J. A. Gladysz, D. P. Curran, I. T. Horváth, Eds. Wiley-VCH, 2004, 359-365

 

P. Nilsson and M. Larhed:

Palladium-Catalyzed Multiple and Asymmetric Arylations of Vinyl Ethers Carrying Coordinating Nitrogen Auxiliaries: Synthesis of Arylated Ketones and Aldehydes.

Catalysts for the Fine Chemical Synthesis, Vol. 3, Metal Catalysed Carbon-Carbon Bond-Forming Reactions, S. M. Roberts, J. Whittall and P. McCormack, Eds. John Wiley and Sons, 2004, 92-99